منابع مشابه
MicroRNA-205 inhibits renal cells apoptosis via targeting CMTM4
Objective(s):MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression. They have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (CKD). In the present study, we elucidated the role of microR...
متن کاملCorrection: Human MicroRNA Targets
We incorrectly named the products of two genes, gamma actin and betaAPP, as FMRP ligands because of a misreading of Table 1 from [1]. BetaAPP is incorrectly referred to as an FMRP ligand in Tables 2 and S9, gamma actin in Table S9 only. This does not change the use of FMRP binding as a way to support the target predictions, as the statistics remain virtually the same; the enrichment of FMRP tar...
متن کاملHuman MicroRNA Targets
MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the message or inhibit translation. The specific function of most mammalian miRNAs is unknown. We have predicted target sites on the 3' untranslated regions of human gene transcripts for all currently known 218 mammalian miRNAs to facilitate focused experiments. We report about 2,000 human genes with miRNA tar...
متن کاملRedefining MicroRNA Targets
Animal microRNAs (miRNAs) guide proteins to repress the translation of target mRNAs via imperfect base pairing between the miRNA and the target. Computational analyses suggest that each miRNA regulates tens or hundreds of targets [1, 2], yet genetic studies usually show that the repression of a few targets plays a physiological role [3-5]. The extent of miRNA-mediated repression (which rarely e...
متن کاملmicrorna-205 inhibits renal cells apoptosis via targeting cmtm4
objective(s):micrornas (mirnas) are small non-coding rna molecules that regulate gene expression. they have important roles in kidney development, homeostasis and disease, and participate in the onset and progression of tubulointerstitial sclerosis and end-stage glomerular lesions that occur in various forms of chronic kidney disease (ckd). in the present study, we elucidated the role of micror...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2012
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.112.276717